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pentobarbital will minimize the extent or effect of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can minimize panobinostat levels by ~70% and lead to cure failure.ADVERSE REACTI